Flucytosine (5-FC, 5-Fluorocytosine)



Flucytosine (5-FC, 5-Fluorocytosine)





(floo sye’ toe seen)

Ancobon

PREGNANCY CATEGORY C


Drug Class

Antifungal


Therapeutic Actions

Affects cell membranes of susceptible fungi to cause fungus death; exact mechanism of action is not understood.


Indications



  • Treatment of serious infections caused by susceptible strains of Candida, Cryptococcus



Contraindications and Cautions



  • Contraindicated with allergy to flucytosine, pregnancy, lactation.


  • Use cautiously with renal impairment (drug accumulation and toxicity may occur), hepatic impairment, bone marrow depression.


Available Forms

Capsules—250, 500 mg


Dosages

Adults

50–150 mg/kg/day PO at 6-hr intervals.

Pediatric patients

Safety and efficacy not established.

Patients with renal impairment

Adjust dosing interval based on CrCl: maintain blood levels below 100 mcg/mL.



















CrCl (mg/mL) Dosing interval
20–40 Every 12 hr
10–20 Every 24 hr
Less than 10 Every 24–48 hr

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Jul 21, 2016 | Posted by in NURSING | Comments Off on Flucytosine (5-FC, 5-Fluorocytosine)

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