Fingolimod(fin gol ih mod)
Gilenya
PREGNANCY CATEGORY C
Drug Classes
MS drug
Sphingosine 1-phosphate receptor modulator
Therapeutic Actions
By blocking sphingosine 1-phosphate receptors, drug blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood. Mechanism of action in MS is not known; thought to be related to the reduction of lymphocyte migration into the CNS.
Indications
Treatment of relapsing forms of MS to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability
Contraindications and Cautions
Contraindicated with known hypersensitivity to components of drug; MI, angina, heart block, HF, prolonged QT interval, concurrent use of antiarryhthmics, lactation.
Use cautiously with hepatic impairment, slow heart rate, active infection, diabetes with macular edema or uveitis, hypertension, pregnancy.
Available Forms
Capsules—0.5 mg
Dosages
Adults
0.5 mg/day PO; monitor patient for bradycardia for at least 6 hr after first dose.
Pediatric patients younger than 18 yr
Safety and efficacy not established.
Pharmacokinetics
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