Febuxostat(feh bux’ oh stat)
Uloric
PREGNANCY CATEGORY C
Drug Classes
Antigout drug
Xanthine oxidase inhibitor
Therapeutic Actions
Blocks xanthine oxidase, an important enzyme in the process of uric acid formation; not thought to affect other enzymes involved in purine or pyrimidine synthesis.
Indications
Long-term management of hyperuricemia in patients with gout
Contraindications and Cautions
Contraindicated with hypersensitivity to components of drug, concurrent treatment with azathioprine, mercaptopurine, or theophyllines.
Use cautiously with severe renal or hepatic impairment, history of heart attack or stroke, pregnancy, lactation.
Available Forms
Tablets—40, 80 mg
Dosages
Adults
Initially, 40 mg/day PO; if serum uric acid level is not less than 6 mg/dL in 2 weeks, dosage may be increased to 80 mg/day PO.
Pediatric patients
Safety and efficacy not established.
Patients with renal or hepatic impairment
No dosage change required with mild to moderate impairment; use caution with severe impairment (Child-Pugh Class C).
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