Fat Emulsion, IntravenousIntralipid 20%, 30%; Liposyn II 10%, 20%; Liposyn III 10%, 20%, 30%
PREGNANCY CATEGORY C
Drug Classes
Caloric drug
Nutritional drug
Therapeutic Actions
A preparation from soybean or safflower oil that provides neutral triglycerides, mostly unsaturated fatty acids; these are used as a source of energy, causing an increase in heat production, decrease in respiratory quotient, and increase in oxygen consumption.
Indications
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Source of calories and essential fatty acids for patients requiring parenteral nutrition for extended periods
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Essential fatty acid deficiency
Contraindications and Cautions
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Contraindicated with disturbance of normal fat metabolism (hyperlipemia, lipoid nephrosis, acute pancreatitis), allergy to eggs.
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Use cautiously with severe liver damage, pulmonary disease, anemia, blood coagulation disorders, pregnancy, jaundiced or premature infants.
Available Forms
Injection—10% (100, 200, 500 mL), 20% (50, 100, 250, 500 mL); 30% (500 mL)
Dosages
Adults
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Parenteral nutrition: Should not constitute more than 60% of total calorie intake. 10%: Infuse IV at 1 mL/min for the first 15–30 min; may be increased to 2 mL/min. Infuse only 500 mL the first day, and increase the following day. Do not exceed 2.5 g/kg/day. 20%: Infuse at 0.5 mL/min for the first 15–30 min; infuse only 250 mL Liposyn II or 500 mL Intralipid the first day, and increase the following day. Do not exceed 3 g/kg/day. 30%: Infuse at 1 mL/min (0.1 g fat/min) for first 15–30 min; do not exceed 2.5 g/kg/day.
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Fatty acid deficiency: Supply 8%–10% of the caloric intake by IV fat emulsion.
Pediatric patients
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Parenteral nutrition: Should not constitute more than 60% of total calorie intake. 10%: Initial IV infusion rate is 0.1 mL/min for the first 10–15 min. 20%: Initial infusion rate is 0.05 mL/min for the first 10–15 min. If no untoward reactions occur, increase rate to 1 g/kg in 4 hr. Do not exceed 3 g/kg/day. 30%: Initial infusion, 0.1 mL/min (0.01 g fat/min) for first 10–15 min; do not exceed 3 g/kg/day.
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