Reduction of the signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis; to delay the structural damage associated with rheumatoid arthritis; or may be used in combination with methotrexate when patients do not respond to methotrexate alone

Reduction of signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients 2 yr and older

Reduction of signs and symptoms and to improve function in patients with psoriatic arthritis; may be used alone or in combination with methotrexate

Treatment of ankylosing spondylitis

Treatment of adult patients with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy

Unlabeled uses: Heart failure, Crohn disease, graft-versus-host disease, hidradenitis suppurativa, nephrotic syndrome, pyoderma gangrenosum