Ertapenem(er tah pen’ em)
Invanz
PREGNANCY CATEGORY B
Drug Classes
Antibiotic
Methyl-carbapenem
Therapeutic Actions
Bactericidal: Inhibits synthesis of susceptible bacterial cell wall causing cell death.
Indications
Community-acquired pneumonia caused by Streptococcus pneumoniae (penicillin-susceptible strains only), Haemophilus influenzae (beta-lactamase–negative strains only), Moraxella catarrhalis
Complicated skin and skin-structure infections including diabetic foot infections without osteomyelitis caused by Staphylococcus aureus (methicillin-susceptible strains only), Streptococcus pyogenes, Escherichia coli, Streptococcus agalactiae, Klebsiella pneumoniae, Proteus mirabilis, Bacteroides fragilis, Porphyromonas asaccharolytica, Prevotella bivia, Peptostreptococcus species
Complicated GU infections, including pyelonephritis caused by E. coli or K. pneumoniae.
Complicated intra-abdominal infections due to E. coli, Clostridium clostridiiforme, Eubacterium lentum, Peptostreptococcus species, B. fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides uniformis
Acute pelvic infections, including postpartum endomyometritis, septic abortion, postsurgical gynecologic infections due to S. agalactiae, E. coli, B. fragilis, P. asaccharolytica, Peptostreptococcus species, P. bivia
Prophylaxis of surgical-site infection after elective colorectal surgery in adults
Unlabeled use: Hospital-acquired pneumonia, catheter-related bloodstream infections
Contraindications and Cautions
Contraindicated with allergies to any component of the drug and to beta-lactam antibiotics; allergy to amide-type local anesthetics (IM use); allergy to penicillins, cephalosporins, other allergens.
Use cautiously with pregnancy; lactation, seizure disorder.
Available Forms
Vials for reconstitution—1 g/vial
Dosages
Adults and children 13 yr and older
1 g IM or IV each day; length of treatment varies with infection—intra-abdominal, 5–14 days; urinary tract, 10–14 days; skin and skin structure, 7–14 days; community-acquired pneumonia, 10–14 days; acute pelvic infections, 3–10 days.
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