Efavirenz(eff ah vye’ renz)
SustivaDNC
PREGNANCY CATEGORY D
Drug Classes
Antiviral
Non-nucleoside reverse transcriptase inhibitor
Therapeutic Actions
A non-nucleoside reverse transcriptase inhibitor shown to be effective in suppressing the HIV virus in adults and children.
Indications
Treatment of HIV and AIDS in adults and children at least 3 mo and weighing at least 3.5 kg, when used in combination with other antiretroviral drugs
Contraindications and Cautions
Contraindicated with life-threatening allergy to any component, lactation.
Use cautiously with hepatic impairment, hypercholesterolemia, psychiatric disorders, pregnancy.
Available Forms
CapsulesDNC—50, 200 mg; tabletsDNC—600 mg
Dosages
Adults
600 mg PO daily in conjunction with a protease inhibitor or other nucleoside reverse transcriptase inhibitor. If in combination with voriconazole 400 mg PO every 12 hr: 300 mg/day efavirenz PO using capsule form. If in combination with rifampin, patients weighing 50 kg or more, increase efavirenz to 800 mg/day PO.
Pediatric patients 3 mo and older
Dosage, given at bedtime, is based on weight of child as follows:
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Pharmacokinetics
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