Dolutegravir(do loot ah grah veer)
Tivicay
PREGNANCY CATEGORY B
Drug Classes
Antiviral
Integrase inhibitor
Therapeutic Actions
Antiviral, inhibits the virus-specific enzyme intergase, an encoded enzyme needed for viral replication, preventing formation of HIV-a provirus, which leads to decreased viral load and increased active CD4 cells.
Indications
Treatment of HIV-1 infection in adults and children 12 yr and older in combination with other antiretroviral agents
Contraindications and Cautions
Contraindicated with history of serious hypersensitivity reactions to drug or its components; concurrent use of dofetilide; lactation.
Use caution with pregnancy, concurrent use of any cation-containing medications.
Available Forms
Tablets—50 mg
Dosages
Adults and children 12 yr and older, weighing at least 40 kg
50 mg/day PO; when taken with efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin–50 mg PO bid; with suspected resistance–50 mg PO bid
Pharmacokinetics
|
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
