Diclofenac(dye kloe’ fen ak)
Zorvolex
Diclofenac Epolamine
Flector, Pennsaid, Solaraze, Voltaren
Diclofenac Potassium
Apo-Diclo Rapide (CAN), Cambia, Cataflam, Novo-Difenac-K (CAN), Voltaren Rapide (CAN), Zipsor
Diclofenac Sodium
Apo-Diclo (CAN), Apo-Diclo SRDNC, Novo-Difenac (CAN), Novo-Difenac SR (CAN), Nu-Diclo (CAN), Nu-Diclo SR (CAN)DNC, PMS-Diclofenac (CAN), PMS-Diclofenac SR (CAN)DNC, Solaraze, Voltaren Ophtha (CAN), Voltaren-XRDNC
PREGNANCY CATEGORY C (FIRST AND SECOND TRIMESTERS)
PREGNANCY CATEGORY D (THIRD TRIMESTER)
Drug Classes
Analgesic (nonopioid)
Anti-inflammatory
Antipyretic
NSAID
Therapeutic Actions
Inhibits prostaglandin synthetase to cause antipyretic and anti-inflammatory effects; the exact mechanism is unknown.
Indications
Acute or long-term treatment of mild to moderate pain, including dysmenorrhea
Rheumatoid arthritis
Acute treatment of migraine headache with or without aura (Cambia)
Osteoarthritis
Ankylosing spondylitis
Treatment of actinic keratosis in conjunction with sun avoidance (topical only)
Topical treatment of acute pain due to minor strains, sprains, contusions (Flector)
Treatment of mild to moderate acute pain in adults (Zorvolex)
Ophthalmic: Postoperative inflammation from cataract extraction
Contraindications and Cautions
Contraindicated with allergy to NSAIDs, significant renal impairment, pregnancy, lactation.
Use cautiously with impaired hearing, allergies, hepatic, CV, GI conditions, and in elderly patients.
Available Forms
Tablets—50 mg; DR tabletsDNC—25, 50, 75 mg; ER tabletsDNC—100 mg; liquid-filled capsules—25 mg; capsules—18, 35 mg; packet for oral solution—50 mg; topical gel—1%, 3%; topical solution—1.5%; ophthalmic solution—0.1%; transdermal patch—180 mg
Dosages
Adults
Oral
Pain, including dysmenorrhea: 50 mg tid PO; initial dose of 100 mg may help some patients (Cataflam).
Osteoarthritis: 100–150 mg/day PO in divided doses; 50 mg bid–tid PO (Cataflam).
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