Dextran, Low-Molecular-Weight(dex’ tran)
Dextran 40, Gentran 40, 10% LMD, Rheomacrodex
PREGNANCY CATEGORY C
Drug Classes
Plasma volume expander (nonbacteriostatic)
Therapeutic Actions
Synthetic polysaccharide used to approximate the colloidal properties of albumin.
Indications
Adjunctive therapy for treatment of shock or impending shock due to hemorrhage, burns, surgery, or trauma when blood or blood products are not available
Priming fluid in pump oxygenators during extracorporeal circulation
Prophylaxis against DVT and PE in patients undergoing procedures known to be associated with a high incidence of thromboembolic complications, such as hip surgery
Contraindications and Cautions
Contraindicated with allergy to dextran (dextran 1 can be used prophylactically in patients known to be allergic to clinical dextran); marked hemostatic defects; severe cardiac congestion; renal failure, anuria, or oliguria.
Use cautiously with pregnancy, lactation.
Available Forms
Injection—10% Dextran 40 in 0.9% sodium chloride, 10% Dextran 40 in 5% dextrose
Dosages
Adults
Adjunctive therapy in shock: Total dosage of 20 mL/kg IV in first 24 hr. The first 10 mL/kg should be infused rapidly, and the remaining dose administered slowly. Beyond 24 hr, total daily dosage should not exceed 10 mL/kg. Do not continue therapy for more than 5 days.
Hemodiluent in extracorporeal circulation: Generally, 10–20 mL/kg are added to
perfusion circuit. Do not exceed a total dosage of 20 mL/kg.
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