Dexmethylphenidate Hydrochloride(decks meth ill fen’ i date)
Focalin, Focalin XRDNC
PREGNANCY CATEGORY C
CONTROLLED SUBSTANCE C-II
Drug Classes
CNS stimulant
Therapeutic Actions
Mild cortical stimulant with CNS actions similar to those of the amphetamines; is thought to block the reuptake of norepinephrine and dopamine, increasing their concentration in the synaptic cleft; mechanism of effectiveness in hyperkinetic syndromes is not understood.
Indications
Treatment of ADHD in patients 6 yr and older as part of a total treatment program
Contraindications and Cautions
Contraindicated with hypersensitivity to dexmethylphenidate or methylphenidate; marked anxiety, tension, and agitation; glaucoma; motor tics, family history or diagnosis of Tourette syndrome; use of MAOIs within the past 14 days.
Use cautiously with psychosis, seizure disorders; heart failure, recent MI, hyperthyroidism; drug dependence, alcoholism, severe depression of endogenous or exogenous origin; as treatment of normal fatigue states; pregnancy, lactation.
Available Forms
Tablets—2.5, 5, 10 mg; ER capsulesDNC—5, 10, 15, 20, 30, 35, 40 mg
Dosages
Adults and children 6 yr and older
Individualize dosage. Administer orally twice a day, at least 4 hr apart, without regard to
meals. Starting dose, 2.5 mg PO bid; may increase as needed in 2.5- to 5-mg increments to a maximum dose of 10 mg PO bid. ER capsules, initially, 5 mg/day for children; increase in 5-mg increments to 30 mg/day; start adults at 10 mg/day; increase in 10-mg increments to 40 mg/day.
meals. Starting dose, 2.5 mg PO bid; may increase as needed in 2.5- to 5-mg increments to a maximum dose of 10 mg PO bid. ER capsules, initially, 5 mg/day for children; increase in 5-mg increments to 30 mg/day; start adults at 10 mg/day; increase in 10-mg increments to 40 mg/day.
Patients already on methylphenidate: Start dose at one-half the methylphenidate dose with a maximum dose of 10 mg PO bid.
Pediatric patients younger than 6 yr
Safety and efficacy not established.
Pharmacokinetics
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