Dangerous Drug: Saxagliptin Hydrochloride(sacks ah glip’ ten)
Onglyza
PREGNANCY CATEGORY B
Drug Classes
Antidiabetic drug
DPP-4 (dipeptidyl peptidase-4) enzyme inhibitor
Therapeutic Actions
Slows the inactivation of the incretin hormones, increasing these hormone levels and prolonging their activity. The incretin hormones stimulate insulin release in response to a meal and help regulate glucose homeostasis throughout the day. This increases and prolongs insulin release and reduces hepatic glucose production to help achieve glycemic control.
Indications
As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes
Contraindications and Cautions
Contraindicated with history of serious hypersensitivity reactions to saxagliptin; type 1 diabetes, diabetic ketoacidosis.
Use cautiously with moderate or severe renal impairment, concurrent use of strong CYP3A inhibitors, pregnancy, lactation.
Available Forms
Tablets—2.5, 5 mg
Pharmacokinetics
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