Dangerous Drug: Nateglinide(nah teg’ lah nyde)
Starlix
PREGNANCY CATEGORY C
Drug Classes
Antidiabetic
Meglitinide
Therapeutic Actions
Closes potassium channels in the beta cells of the pancreas, which causes the opening of calcium channels and a resultant increase in insulin release; highly selective for pancreatic potassium channels with little effect on the vasculature. Glucose-lowering abilities depend on the existence of functioning beta cells in the pancreas.
Indications
Adjunct to diet and exercise to lower blood glucose in patients with type 2 diabetes mellitus whose hyperglycemia cannot be managed by diet and exercise alone
Combination therapy with metformin or a thiazolidinedione for glycemic control in those patients with type 2 diabetes who do not receive adequate control with diet and either drug
Contraindications and Cautions
Contraindicated with hypersensitivity to the drug, diabetic ketoacidosis, type 1 diabetes, pregnancy, lactation.
Use cautiously with hepatic impairment.
Available Forms
Tablets—60, 120 mg
Dosages
Adults
120 mg PO tid taken 1–30 min before meals; 60 mg PO tid may be tried if patient is near HbA1c goal.
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