Dangerous Drug: Isoproterenol(eye soe proe ter’ e nole)
Dangerous Drug: Isoproterenol Hydrochloride
Isuprel
PREGNANCY CATEGORY C
Drug Classes
Antiasthmatic
Beta1– and beta2-adrenergic agonist
Bronchodilator
Sympathomimetic
Vasopressor in shock
Therapeutic Actions
Effects are mediated by beta1– and beta2-adrenergic receptors; acts on beta1-receptors in the heart to produce positive chronotropic and positive inotropic effects and to increase automaticity; acts on beta2-receptors in the bronchi to cause bronchodilation; acts on beta2-receptors in smooth muscle in the walls of blood vessels in skeletal muscle and splanchnic beds to cause dilation (cardiac stimulation, vasodilation may be adverse effects when drug is used as bronchodilator).
Indications
Management of bronchospasm during anesthesia; a vasopressor in shock
Adjunct in the management of shock (hypoperfusion syndrome) and in the treatment of cardiac standstill or arrest; carotid sinus hypersensitivity; heart block; Stokes-Adams syndrome; heart failure; ventricular tachycardia and ventricular arrhythmias that require increased inotropic activity for therapy
Contraindications and Cautions
Contraindicated with hypersensitivity to isoproterenol; tachyarrhythmias, tachycardia caused by digoxin toxicity; acute angina; general anesthesia with halogenated hydrocarbons or cyclopropane (sensitize the myocardium to catecholamines); labor and delivery (may delay second stage of labor; can accelerate fetal heart beat; may cause hypoglycemia, hypokalemia, pulmonary edema in the mother, and hypoglycemia in the neonate).
Use cautiously with unstable vasomotor system disorders, hypertension, coronary insufficiency, history of stroke, COPD patients with degenerative heart disease, diabetes mellitus, hyperthyroidism, history of seizure disorders, psychoneuroses, lactation, pregnancy.
Available Forms
Injection—0.02 mg/mL (1:50,000), 0.2 mg/mL (1:5,000)
Dosages
Adults
Injection
Bronchospasm during anesthesia: 0.01–0.02 mg (0.5–1 mL of diluted solution) bolus IV; repeat when necessary.
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