Dangerous Drug: Heparin Sodium(hep’ ah rin)
Dangerous Drug: Heparin Sodium and 0.9% Sodium Chloride Heparin Sodium and 0.45% Sodium Chloride Heparin Sodium Injection
Hepalean (CAN), Heparin LEO (CAN)
Dangerous Drug: Heparin Sodium Lock Flush Solution
Hepalean-Lok (CAN), Heparin IV Flush, Heparin Lock Flush, Hepflush-10, Hep-Lock, Hep-Lock U/P
PREGNANCY CATEGORY C
Drug class
Anticoagulant
Therapeutic Actions
Heparin inactivates factor Xa, therefore inhibiting thrombus and clot formation by blocking the conversion of prothrombin to thrombin and fibrinogen to fibrin, the final steps in the clotting process. Heparin also inhibits the activation of factor XIII and thrombin-induced activation of factors V and VIII
Indications
Prevention and treatment of venous thrombosis, pulmonary embolism, and peripheral arterial embolism
Treatment of atrial fibrillation with embolization
Diagnosis and treatment of DIC
Prevention of clotting in blood samples and heparin lock sets and during dialysis procedures
Unlabeled uses: Adjunct in therapy of coronary occlusion with acute MI, prevention of left ventricular thrombi and stroke post-MI, prevention of cerebral thrombosis in the evolving stroke
Contraindications and Cautions
Contraindicated with hypersensitivity to heparin; severe thrombocytopenia; uncontrolled bleeding; any patient who cannot be monitored regularly with blood coagulation tests; in pediatric patients if using injection preserved with benzyl alcohol, which can lead to death in pediatric patients; labor and immediate postpartum period.
Use cautiously with pregnancy; women older than 60 yr who are at high risk for hemorrhaging, dysbetalipoproteinemia; recent surgery or injury.
Available Forms
Injection—1,000, 2,500, 5,000, 10,000, 20,000 units/mL; also single-dose and unit-dose forms; lock flush solution—1, 10, 100 units/mL
Dosages
Adjust dosage according to coagulation tests. Dosage is adequate when WBCT = 2.5–3 times control—or aPTT = 1.5–2 times control value. The following are guidelines to dosage:
Adults Subcutaneous (deep subcutaneous injection)
For general anticoagulation: IV loading dose of 5,000 units and then 10,000–20,000 units subcutaneously followed by 8,000–10,000 units every 8 hr or 15,000–20,000 units every 12 hr.
Prophylaxis of postoperative thromboembolism: 5,000 units by deep subcutaneous injection 2 hr before surgery and every 8–12 hr thereafter for 7 days or until patient is fully ambulatory.
IV
Intermittent IV: Initial dose of 10,000 units and then 5,000–10,000 units every 4–6 hr.
Continuous IV infusion: Loading dose of 5,000 units and then 20,000–40,000 units/day.
Surgery of heart and blood vessels for patients undergoing total body perfusion: Not less than 150 units/kg; guideline often used is 300 units/kg for procedures less than 60 min, 400 units/kg for longer procedures. Add 400–600 units to 100 mL whole blood.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
