Dangerous Drug: Dobutamine Hydrochloride(doe’ byoo ta meen)
PREGNANCY CATEGORY B
Drug Classes
Beta1-selective adrenergic agonist
Sympathomimetic
Therapeutic Actions
Positive inotropic effects are mediated by beta1-adrenergic receptors in the heart; increases the force of myocardial contraction with relatively minor effects on heart rate, arrhythmogenesis; has minor effects on blood vessels.
Indications
For inotropic support in the short-term treatment of cardiac decompensation due to depressed contractility, resulting from either organic heart disease or from cardiac surgical procedures
Unlabeled uses: In children with congenital heart disease undergoing diagnostic cardiac catheterization, to augment CV function
Contraindications and Cautions
Contraindicated with IHSS; hypovolemia (dobutamine is not a substitute for blood, plasma, fluids, electrolytes, which should be restored promptly when loss has occurred and in any case before treatment with dobutamine); acute MI (may increase the size of an infarct by intensifying ischemia); general anesthesia with halogenated hydrocarbons
or cyclopropane, which sensitize the myocardium to catecholamines; pregnancy.
Use cautiously with diabetes mellitus, lactation; allergy to sulfites, more common in asthmatic patients.
Available Forms
Injection—12.5 mg/mL; injection in 5% dextrose injection—1 mg/mL, 2 mg/mL, 4 mg/mL
Indications
Administer only by IV infusion using an infusion pump or other device to control the rate of flow. Titrate on the basis of the patient’s hemodynamic and renal responses. Close monitoring is necessary.
