Cyclizine(sye’ kli zeen)
Marezine
PREGNANCY CATEGORY B
Drug Classes
Anticholinergic
Antiemetic
Antihistamine
Anti–motion-sickness drug
Therapeutic Actions
Reduces sensitivity of the labyrinthine apparatus; peripheral anticholinergic effects may contribute to efficacy.
Indications
Prevention and treatment of nausea, vomiting, dizziness associated with motion sickness
Contraindications and Cautions
Contraindicated with allergy to cyclizine.
Use cautiously with pregnancy, lactation, narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bronchial asthma, bladder neck obstruction, pyloroduodenal obstruction, cardiac arrhythmias; postoperative patients (hypotensive effects may be confusing and dangerous).
Available Forms
Tablets—25, 50 mg
Dosages
Adults
50 mg PO 30 min before exposure to motion; repeat every 4–6 hr. Do not exceed 200 mg in 24 hr.
Pediatric patients 6–12 yr
25 mg PO up to three times a day; maximum dose, 75 mg/day.
Geriatric patients
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