Clotrimazole(kloe trim’ a zole)
Oral, Topical use only: Generic
Vaginal preparations: Canesten Vaginal (CAN), Gyne-Lotrimin 3, Gyne-Lotrimin 3 Combination Pack, Mycelex-7, Mycelex-7 Combination Pack
Topical preparations: Canesten Topical (CAN), Clotrimaderm (CAN), Cruex, Desenex, Fungoid, Lotrimin AF, Lotrimin Ultra
PREGNANCY CATEGORY B (TOPICAL, VAGINAL FORMS)
PREGNANCY CATEGORY C (ORAL TROCHE)
Drug Classes
Antifungal
Therapeutic Actions
Fungicidal and fungistatic: Binds to fungal cell membrane with a resultant change in membrane permeability, allowing leakage of intracellular components, causing cell death.
Indications
Troche: Treatment of oropharyngeal candidiasis; prevention of oropharyngeal candidiasis in immunocompromised patients receiving radiation, chemotherapy, or steroid therapy
Vaginal preparations: Local treatment of vulvovaginal candidiasis (moniliasis)
Contraindications and Cautions
Contraindicated with allergy to clotrimazole or components used in preparation. Vaginal products contraindicated in girls younger than 12 yr.
Use vaginal and topical preparations cautiously with pregnancy, lactation.
Use oral troche only when benefits to mother outweigh risk to fetus.
Available Forms
Vaginal suppositories—100, 200 mg; vaginal cream, solution, lotion—1%, 2%; topical cream, solution, lotion—1%; oral troche—10 mg
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