Cimetidine(sye met’ i deen)
Apo-Cimetidine (CAN), Gen-Cimetidine (CAN), Nu-Cimet (CAN), Tagamet, Tagamet HB
PREGNANCY CATEGORY B
Drug Classes
Histamine2 (H2) antagonist
Therapeutic Actions
Inhibits the action of histamine at the H2 receptors of the stomach, inhibiting gastric acid secretion and reducing total pepsin output.
Indications
Short-term treatment and maintenance of active duodenal ulcer
Short-term treatment of benign gastric ulcer
Treatment of pathologic hypersecretory conditions (Zollinger-Ellison syndrome)
Prophylaxis of stress-induced ulcers and acute upper GI bleeding in critical patients
Treatment of erosive GERD
OTC use: Relief of symptoms of heartburn, acid indigestion, sour stomach
Unlabeled uses: Part of multidrug regimen for Helicobacter pylori; urticaria, warts, interstitial cystitis
Contraindications and Cautions
Contraindicated with allergy to cimetidine.
Use cautiously with impaired renal or hepatic function, lactation, pregnancy.
Available Forms
Tablets—200, 300, 400, 800 mg; liquid—300 mg/5 mL; injection—150 mg/mL
Dosages
Adults
Active duodenal ulcer: 800 mg PO at bedtime or 300 mg PO qid with meals and at bedtime or 400 mg PO bid; continue for 4–6 wk unless healing is demonstrated by endoscopy. For intractable ulcers, 300 mg IM or IV every 6–8 hr.
Maintenance therapy for duodenal ulcer: 400 mg PO at bedtime.
Active benign gastric ulcer: 300 mg PO qid with meals and at bedtime or 800 mg at bedtime. Treat for 8 wk.
Pathologic hypersecretory syndrome: 300 mg PO qid with meals and at bedtime, or 300 mg IV or IM every 6 hr. Individualize doses as needed; do not exceed 2,400 mg/day.
Erosive GERD: 1,600 mg PO in divided doses bid–qid for 12 wk.
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