Cilostazol(sill ahs’ tah zoll)
Pletal
PREGNANCY CATEGORY C
Drug Classes
Antiplatelet
Therapeutic Actions
Reversibly inhibits platelet aggregation induced by a variety of stimuli including ADP, thrombin, collagen, shear stress, epinephrine, and arachidonic acid by inhibiting cAMP phosphodiesterase III; produces vascular dilation in vascular beds with a specificity for femoral beds; seems to have no effect on renal arteries.
Indications
Reduction of symptoms of intermittent claudication allowing increased walking distance
Contraindications and Cautions
Contraindicated with allergy to cilostazol, heart failure of any severity (decreased survival rates have occurred), active bleeding, hemostatic disorders.
Use cautiously with pregnancy, lactation, renal dysfunction.
Available Forms
Tablets—50, 100 mg
Dosages
Adults
100 mg PO bid taken at least 30 min before or 2 hr after breakfast and dinner. Response may not be noted for 2–4 wk and may take up to 12 wk.
Pediatric patients
Safety and efficacy not established.
Pharmacokinetics
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