Chlorthalidone(klor thal’ i done)
Apo-Chlorthalidone (CAN), Thalitone
PREGNANCY CATEGORY B
Drug Class
Thiazide-like diuretic
Therapeutic Actions
Inhibits reabsorption of sodium and chloride in distal renal tubule, increasing excretion of sodium, chloride, and water by the kidneys.
Indications
Adjunctive therapy in edema associated with heart failure, cirrhosis, corticosteroid and estrogen therapy, renal impairment
Hypertension, alone or with other antihypertensives
Unlabeled use: Pediatric hypertension
Contraindications and Cautions
Contraindicated with anuria, renal failure, allergy to any thiazides or sulfonamides, hepatic coma.
Use cautiously with fluid or electrolyte imbalances, renal or hepatic disease, gout, SLE, glucose tolerance abnormalities, hyperparathyroidism, manic-depressive disorders, lactation, pregnancy.
Available Forms
Tablets—15, 25, 50, 100 mg
Dosages
Adults
Edema: 50–100 mg/day PO or 100 mg PO every other day; up to 200 mg/day. Or 30–60 mg/day PO or 60 mg PO every other day, up to 120 mg/day. (Thalitone)
Hypertension: Initiate with 25 mg/day; if response is insufficient, increase to 50 mg/day. If additional control is needed, increase to 100 mg/day or add a second antihypertensive. Increases in serum uric acid and decreases in serum potassium are dose-related over the 25–100 mg/day range. Or 15 mg/day PO, may be increased to 30, 45, or 50 mg/day as a single dose (Thalitone); if control is still not achieved, add a second antihypertensive.
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