Chloroquine Phosphate(klo’ ro kwin)
Aralen Phosphate
PREGNANCY CATEGORY C
Drug Classes
4-aminoquinoline
Amebicide
Antimalarial
Therapeutic Actions
Inhibits protozoal reproduction and protein synthesis. Mechanism of anti-inflammatory action in rheumatoid arthritis is not known.
Indications
Treatment of extraintestinal amebiasis
Prophylaxis and treatment of acute attacks of malaria caused by susceptible strains of Plasmodia
Unlabeled use: Treatment of rheumatoid arthritis (150 mg PO daily)
Contraindications and Cautions
Contraindicated with allergy to chloroquine and other 4-aminoquinolines; retinal or visual field changes.
Use cautiously with porphyria, psoriasis, retinal disease, hepatic disease, G6PD deficiency, alcoholism, lactation, pregnancy.
Available Forms
Tablets—250, 500 mg
Dosages
Warning Dosage is often expressed as chloroquine base.Adults
Amebiasis: 1 g (600 mg base)/day PO for 2 days; then 500 mg (300 mg base)/day for 2–3 wk.
Malaria: For suppression, 300 mg base (500 mg) PO once a week on the same day for 2 wk before exposure and continuing until 8 wk after exposure. For acute attack, initially, 600 mg base (1 g) PO; then 300 mg base (500 mg) 6–8 hr, 24 hr, 48 hr after the initial dose for a total dose of 1.5 g base (2.5 g) in 3 days.
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