Cephalexin(sef a lex’ in)
Apo-Cephalex (CAN), Keflex, Novo-Lexin (CAN), Nu-Cephalex (CAN)
PREGNANCY CATEGORY B
Drug Classes
Antibiotic
Cephalosporin (first generation)
Therapeutic Actions
Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death.
Indications
Respiratory tract infections caused by Streptococcus pneumoniae, group A beta-hemolytic streptococci
Skin and skin-structure infections caused by staphylococcus, streptococcus
Otitis media caused by S. pneumoniae, Haemophilus influenzae, streptococcus, staphylococcus, Moraxella catarrhalis
Bone infections caused by staphylococcus, Proteus mirabilis
GU infections caused by Escherichia coli, P. mirabilis, Klebsiella
Contraindications and Cautions
Contraindicated with allergy to cephalosporins or penicillins.
Use cautiously with renal failure, lactation, pregnancy.
Available Forms
Capsules—250, 500, 750 mg; tablets—250, 500 mg; oral suspension—125 mg/5 mL, 250 mg/5 mL
Dosages
Adults
1–4 g/day in divided doses; 250 mg PO every 6 hr usual dose.
Skin and skin-structure infections, streptococcal pharyngitis, uncomplicated cystitis: 500 mg PO every 12 hr. Larger doses may be needed in severe cases; do not exceed 4 g/day.
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