Cefuroxime(se fyoor ox’ eem)
Cefuroxime Axetil
CeftinDNC
Cefuroxime Sodium
Zinacef
PREGNANCY CATEGORY B
Drug Classes
Antibiotic
Cephalosporin (second generation)
Therapeutic Actions
Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death.
Indications
Oral (cefuroxime axetil)
Pharyngitis, tonsillitis caused by Streptococcus pyogenes
Otitis media caused by Streptococcus pneumoniae, S. pyogenes, Haemophilus influenzae, Moraxella catarrhalis
Acute bacterial maxillary sinusitis caused by S. pneumoniae, H. influenzae
Lower respiratory infections caused by S. pneumoniae, Haemophilus parainfluenzae, H. influenzae
UTIs caused by Escherichia coli, Klebsiella pneumoniae
Uncomplicated gonorrhea (urethral and endocervical)
Skin and skin structure infections, including impetigo caused by Streptococcus aureus, S. pyogenes
Treatment of early Lyme disease
Parenteral (cefuroxime sodium)
Lower respiratory infections caused by S. pneumoniae, S. aureus, E. coli, Klebsiella pneuemoniae, H. influenzae, S. pyogenes
Dermatologic infections caused by S. aureus, S. pyogenes, E. coli, K. pneuemoniae, Enterobacter
UTIs caused by E. coli, K. pneumoniae
Uncomplicated and disseminated gonorrhea caused by N. gonorrhoeae
Septicemia caused by S. pneumoniae, S. aureus, E. coli, K. pneumoniae, H. influenzae
Meningitis caused by S. pneumoniae, H. influenzae, S. aureus, N. meningitidis
Bone and joint infections due to S. aureus
Perioperative prophylaxis
Treatment of acute bacterial maxillary sinusitis in patients 3 mo–12 yr
Contraindications and Cautions
Contraindicated with allergy to cephalosporins or penicillins.
Use cautiously with renal failure, lactation, pregnancy.
Available Forms
TabletsDNC—125, 250, 500 mg; suspension—125 mg/5 mL, 250 mg/5 mL; powder for injection—750 mg, 1.5 g; injection—750 mg, 1.5 g
Dosages
Oral
Adults and patients 12 yr and older
250 mg bid. For severe infections, may be increased to 500 mg bid. Treat for up to 10 days.
Uncomplicated UTIs: 250 mg bid. Treat for 7–10 days.
Uncomplicated gonorrhea: 1,000 mg once as a single dose.
Pediatric patients younger than 12 yr
125 mg bid.
Acute otitis media: 3 mo–12 yr: 250 mg PO bid for 10 days in children who can swallow tablets whole. Or, 30 mg/kg/day
(maximum, 1 g/day) in two divided doses for 10 days (oral solution).
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