Ceftriaxone Sodium(sef try ax’ ohn)
Rocephin
PREGNANCY CATEGORY B
Drug Classes
Antibiotic
Cephalosporin (third generation)
Therapeutic Actions
Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death.
Indications
Lower respiratory infections caused by Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Enterobacter aerogenes, Serratia marcescens, Haemophilus parainfluenzae, Streptococcus (excluding enterococci)
Acute bacterial otitis media caused by S. pneumoniae, H. influenzae, Moraxella catarrhalis
UTIs caused by E. coli, Klebsiella, Proteus vulgaris, Proteus mirabilis, Morganella morganii
Gonorrhea caused by Neisseria gonorrhoeae
Intra-abdominal infections caused by E. coli, Klebsiella pneumoniae
PID caused by N. gonorrhoeae
Skin and skin structure infections caused by S. aureus, Klebsiella, Enterobacter cloacae, P. mirabilis, Staphylococcus epidermidis, Pseudomonas aeruginosa, Streptococcus (excluding enterococci)
Septicemia caused by E. coli, S. pneumoniae, H. influenzae, S. aureus, K. pneumoniae
Bone and joint infections caused by S. aureus, Streptococcus (excluding enterococci), P. mirabilis, S. pneumoniae, E. coli, K. pneumoniae, Enterobacter
Meningitis caused by H. influenzae, S. pneumoniae, Neisseria meningitidis
Perioperative prophylaxis for patients undergoing coronary artery bypass surgery and in contaminated or potentially contaminated surgical procedures (eg, vaginal or abdominal hysterectomy)
Unlabeled uses: Treatment of Lyme disease in doses of 2 g IV daily for 14–28 days, epididymitis, proctitis, proctocolitis, enteritis, gonococcal meningitis, endocarditis
Contraindications and Cautions
Contraindicated with allergy to cephalosporins or penicillins.
Use cautiously with renal failure, lactation, pregnancy.
Available Forms
Powder for injection—250 mg, 500 mg, 1 g, 2 g; injection—1, 2 g
Dosages
Adults
1–2 g/day IM or IV once a day or in equal divided doses bid. Do not exceed 4 g/day.
Gonorrhea: Single 250-mg IM dose.
Meningitis: 1–2 g IM or IV once a day or in equal divided doses bid for 4–14 days.
Longer therapy may be required. Do not exceed 4 g/day.
Perioperative prophylaxis: Give 1 g IV 30–120 min before surgery.
Pediatric patients
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