Ceftibuten

(sef ta byoo’ ten)

Cedax

PREGNANCY CATEGORY B

Drug Classes

Antibiotic

Cephalosporin (third generation)

Therapeutic Actions

Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death.

Indications

• 
  
  Acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae
  
  
• 
  
  Acute bacterial otitis media due to H. influenzae, M. catarrhalis, Streptococcus pyogenes
  
  
• 
  
  Pharyngitis and tonsillitis due to S. pyogenes

Contraindications and Cautions

• 
  
  Contraindicated with allergy to cephalosporins or penicillins.
  
  
• 
  
  Use cautiously with renal failure; lactation, pregnancy.

Available Forms

Capsules—400 mg: oral suspension—90 mg/5 mL, 180 mg/5 mL

Dosages

Adults

400 mg PO daily for 10 days.

Pediatric patients

9 mg/kg/day PO for 10 days to a maximum daily dose of 400 mg/day.

Patients with renal impairment

CrCl (mL/min) Dose More than 50 9 mg/kg or 400 mg PO every 24 hr 30–49 4.5 mg/kg or 200 mg PO every 24 hr 5–29 2.25 mg/kg or 100 mg PO every 24 hr

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