Cefoxitin Sodium(se fox’ i tin)
PREGNANCY CATEGORY B
Drug Classes
Antibiotic
Cephalosporin (second generation)
Therapeutic Actions
Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death.
Indications
Lower respiratory infections caused by Streptococcus pneumoniae, Staphylococcus
aureus, streptococci, Escherichia coli, Klebsiella, Haemophilus influenzae, Bacteroides
Skin and skin structure infections caused by S. aureus, Staphylococcus epidermidis, streptococci, E. coli, Proteus mirabilis, Klebsiella, Bacteroides, Clostridium, Peptococcus, Peptostreptococcus
UTIs caused by E. coli, P. mirabilis, Klebsiella, Morganella morganii, Proteus rettgeri, Proteus vulgaris, Providencia
Uncomplicated gonorrhea caused by Neisseria gonorrhoeae
Intra-abdominal infections caused by E. coli, Klebsiella, Bacteroides, Clostridium
Gynecologic infections caused by E. coli, N. gonorrhoeae, Bacteroides, Clostridium, Peptococcus, Peptostreptococcus, group B streptococci
Septicemia caused by S. pneumoniae, S. aureus, E. coli, Klebsiella, Bacteroides
Bone and joint infections caused by S. aureus
Perioperative prophylaxis
Contraindications and Cautions
Contraindicated with allergy to cephalosporins or penicillins.
Use cautiously with renal failure, lactation, pregnancy.
Available Forms
Powder for injection—1, 2 g; injection—1 g/50 mL, 2 g/50 mL in D5W
Dosages
Adults
1–2 g IM or IV every 6–8 hr, depending on the severity of the infection.
Uncomplicated gonorrhea: 2 g IM with 1 g oral probenecid.
Uncomplicated lower respiratory infections, UTIs, skin infections: 1 g every 6–8 hr IV.
Moderate to severe infections: 1 g every 4 hr IV to 2 g every 6–8 hr IV.
Severe infections: 2 g every 4 hr IV or 3 g every 6 hr IV.
Perioperative prophylaxis: 2 g IV or IM 30–60 min prior to initial incision and every 6 hr for 24 hr after surgery.
Cesarean section: 2 g IV as soon as the umbilical cord is clamped, followed by 2 g IM or IV at 4 and 8 hr, then every 6 hr for up to 24 hr.
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