Cefoxitin Sodium(se fox’ i tin)
PREGNANCY CATEGORY B
Drug Classes
Antibiotic
Cephalosporin (second generation)
Therapeutic Actions
Bactericidal: Inhibits synthesis of bacterial cell wall, causing cell death.
Indications
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Skin and skin structure infections caused by S. aureus, Staphylococcus epidermidis, streptococci, E. coli, Proteus mirabilis, Klebsiella, Bacteroides, Clostridium, Peptococcus, Peptostreptococcus
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UTIs caused by E. coli, P. mirabilis, Klebsiella, Morganella morganii, Proteus rettgeri, Proteus vulgaris, Providencia
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Uncomplicated gonorrhea caused by Neisseria gonorrhoeae
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Intra-abdominal infections caused by E. coli, Klebsiella, Bacteroides, Clostridium
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Gynecologic infections caused by E. coli, N. gonorrhoeae, Bacteroides, Clostridium, Peptococcus, Peptostreptococcus, group B streptococci
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Septicemia caused by S. pneumoniae, S. aureus, E. coli, Klebsiella, Bacteroides
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Bone and joint infections caused by S. aureus
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Perioperative prophylaxis
Contraindications and Cautions
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Contraindicated with allergy to cephalosporins or penicillins.
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Use cautiously with renal failure, lactation, pregnancy.
Available Forms
Powder for injection—1, 2 g; injection—1 g/50 mL, 2 g/50 mL in D5W
Dosages
Adults
1–2 g IM or IV every 6–8 hr, depending on the severity of the infection.
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Uncomplicated gonorrhea: 2 g IM with 1 g oral probenecid.
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Uncomplicated lower respiratory infections, UTIs, skin infections: 1 g every 6–8 hr IV.
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Moderate to severe infections: 1 g every 4 hr IV to 2 g every 6–8 hr IV.
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Severe infections: 2 g every 4 hr IV or 3 g every 6 hr IV.
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Perioperative prophylaxis: 2 g IV or IM 30–60 min prior to initial incision and every 6 hr for 24 hr after surgery.
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Cesarean section: 2 g IV as soon as the umbilical cord is clamped, followed by 2 g IM or IV at 4 and 8 hr, then every 6 hr for up to 24 hr.
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