Carisoprodol (Isomeprobamate)(kar eye soe proe’ dol)
Soma
PREGNANCY CATEGORY C
Drug Classes
Centrally acting skeletal muscle relaxant
Therapeutic Actions
Precise mechanism not known; chemically related to meprobamate, an anxiolytic; has sedative properties; also found in animal studies to inhibit interneuronal activity in descending reticular formation and spinal cord; does not directly relax tense skeletal muscles.
Indications
Relief of discomfort associated with acute, painful musculoskeletal conditions as an adjunct to rest, physical therapy, and other measures
Contraindications and Cautions
Contraindicated with allergic or idiosyncratic reactions to carisoprodol, meprobamate (reported cross-reactions with meprobamate); acute intermittent porphyria, suspected porphyria, lactation.
Use cautiously with renal or hepatic impairment, pregnancy.
Available Forms
Tablets—250, 350 mg
Dosages
Adults and children older than 16 yr
250–350 mg PO tid–qid; take last dose at bedtime for a maximum of 2–3 wk.
Pediatric patients
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