Capreomycin(kap ree oh mye’ sin)
Capastat Sulfate
PREGNANCY CATEGORY C
Drug Classes
Antibiotic
Antituberculotic (“third line”)
Therapeutic Actions
Polypeptide antibiotic; mechanism of action against Mycobacterium tuberculosis unknown.
Indications
Treatment of pulmonary tuberculosis that is not responsive to first-line antituberculosis agents but is sensitive to capreomycin in conjunction with other antituberculosis agents
Contraindications and Cautions
Contraindicated with allergy to capreomycin; preexisting auditory impairment.
Use cautiously with lactation, renal impairment, pregnancy.
Available Forms
Solution for injection—1 g/10 mL
Dosages
Always give in combination with other antituberculotics.
Adults
1 g daily (not to exceed 20 mg/kg/day) IM or IV for 60–120 days, followed by 1 g IM two to three times weekly for 12–24 mo. Can also give IV infusion after further dilution in 100 mL 0.9% sodium chloride and infuse over 60 min.
Pediatric patients
Safety and efficacy have not been established.
Geriatric patients or patients with renal impairment
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