Bisoprolol Fumarate(bis oh’ pro lole few’ mah rate)
Apo-Bisoprolol (CAN), Zebeta
PREGNANCY CATEGORY C
Drug Classes
Antihypertensive
Beta1-selective adrenergic blocker
Therapeutic Actions
Blocks beta-adrenergic receptors (primarily beta1) of the sympathetic nervous system in the heart and juxtaglomerular apparatus (kidney), thus decreasing the excitability of the heart, decreasing cardiac output and oxygen consumption, decreasing the release of renin from the kidneys, and lowering BP.
Indications
Management of hypertension, used alone or with other antihypertensives
Contraindications and Cautions
Contraindicated with sinus bradycardia, second- or third-degree heart block, cardiogenic shock.
Use cautiously with renal failure, diabetes, or thyrotoxicosis (bisoprolol can mask the usual cardiac signs of hypoglycemia and thyrotoxicosis), pregnancy, lactation, and in those with bronchospastic disease, heart failure.
Available Forms
Tablets—5, 10 mg
Dosages
Adults
Initially, 5 mg PO daily, alone or added to diuretic therapy; 2.5 mg may be appropriate; up to 20 mg PO daily has been used.
Pediatric patients
Safety and efficacy not established.
Patients with renal or hepatic impairment
Initially, 2.5 mg PO; adjust, and use extreme caution in dose titration.
Pharmacokinetics
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