Bethanechol Chloride(beh than’ e kole)
PMS-Bethanechol (CAN), Urecholine
PREGNANCY CATEGORY C
Drug Classes
Cholinergic
Parasympathomimetic
Therapeutic Actions
Acts at cholinergic receptors in the urinary bladder (and GI tract) to mimic the effects of acetylcholine and parasympathetic stimulation; increases the tone of the detrusor muscle and causes the emptying of the urinary bladder; not destroyed by the enzyme cholinesterase, so effects are more prolonged than those of acetylcholine.
Indications
Acute postoperative and postpartum nonobstructive urinary retention and neurogenic atony of the urinary bladder with retention
Unlabeled uses: Reflux esophagitis, gastroesophageal reflux (pediatric use)
Contraindications and Cautions
Contraindicated with unusual sensitivity to bethanechol or tartrazine, hyperthyroidism, peptic ulcer, latent or active asthma, bradycardia, vasomotor instability, coronary artery disease, epilepsy, parkinsonism, hypotension, obstructive uropathies or intestinal obstruction, recent surgery on GI tract or bladder.
Use cautiously with lactation, pregnancy.
Available Forms
Tablets—5, 10, 25, 50 mg
Dosages
Determine and use the minimum effective dose; larger doses may increase side effects.
Adults
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