Avanafil(ah van’ ah fil)
Stendra
PREGNANCY CATEGORY C
Drug Classes
Impotence drug
Phosphodiesterase-5 inhibitor
Therapeutic Actions
Selectively inhibits cyclic guanosine monophosphate (cGMP)–specific phosphodiesterase type 5. The mechanism of penile erection involves the release of nitric oxide into the corpus cavernosum of the penis during sexual simulation. Nitric oxide activates cGMP, causing smooth muscle relaxation and allowing the flow of blood into the corpus cavernosum. Phosphodiesterase type 5 is responsible for the deactivation of cGMP; preventing its deactivation leads to prolonged smooth muscle relaxation and increased blood flow. There is no effect in the absence of sexual stimulation.
Indications
Treatment of ED
Contraindications and Cautions
Contraindicated with history of serious hypersensitivity reactions to components of the drug; concurrent use of nitrates. Not for use in women or children.
Use cautiously with alpha blockers or other antihypertensives, CV conditions limiting sexual activity.
Available Forms
Tablets—50, 100, 200 mg
Dosages
Adults
100 mg PO approximately 30 min before sexual activity; no more than one dose/day. May be increased to 200 mg or decreased to 50 mg as needed.
Patients with severe renal or hepatic impairment
Not recommended.
Pharmacokinetics
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