Aripiprazole(air eh pip’ rah zole)
Abilify, Abilify Discmelt, Abilify Maintena
PREGNANCY CATEGORY C
Drug Classes
Atypical antipsychotic
Dopamine, serotonin agonist and antagonist
Psychotropic drug
Therapeutic Actions
Acts as an agonist at dopamine and serotonin sites and antagonist at other serotonin receptor sites.
Indications
Treatment of schizophrenia in patients 13 yr and older
Treatment of major depressive disorder as adjunct to antidepressant therapy
Treatment and maintenance of acute manic and mixed episodes associated with bipolar disorders in patients 10 yr and older
Adjunct to lithium or valproate for acute treatment and maintenance of manic or mixed episodes associated with bipolar disorder in patients 10 yr and older
Irritability associated with autistic disorder in children 6–17 yr
Treatment of agitation associated with schizophrenia or bipolar disorder, manic or mixed (injection)
Unlabeled uses: Restless leg syndrome, cocaine dependence, Tourette syndrome
Contraindications and Cautions
Contraindicated with allergy to aripiprazole, lactation.
Use cautiously with suicidal ideation, pregnancy, cerebral vascular disease or other conditions causing hypotension, known CV disease, seizure disorders, exposure to extreme heat, Alzheimer’s disease, dysphagia (risk for aspiration pneumonia), parkinsonism, elderly patients with dementia-related psychosis.
Available Forms
Tablets—2, 5, 10, 15, 20, 30 mg; oral solution—1 mg/mL; orally disintegrating tablets—10, 15 mg; injection—7.5 mg/mL; ER injection—300, 400 mg/vial
Dosages
Adults
Schizophrenia: 10–15 mg/day PO. Increase dose every 2 wk to maximum of 30 mg/day. Oral solution may be substituted on a mg-to-mg basis up to 25 mg of tablet. Patients taking 30-mg tablets should receive 25 mg if switched to solution. Give 400 mg IM each month if using the ER injection.
Bipolar disorder: 15 mg/day PO as one dose; maintenance dosage, 15–30 mg/day PO. Oral solution may be substituted on a mg-to-mg basis to 25 mg. Patients taking 30-mg tablets should take 25 mg if switched to solution.
Major depressive disorder: Initial dose, 2–5 mg/day PO; maintenance dose, 2–15 mg/day as adjunct therapy. Dose adjustments up to 5 mg/day should occur at intervals of 1 wk or longer.
Agitation: 5.25–15 mg IM; usual dose, 9.75 mg IM. Cumulative doses of up to 30 mg/day may be given.
Pediatric patients 13–17 yr
Pediatric patients 10–17 yr
Bipolar disorder: Initially, 2 mg/day PO; titrate to 5 mg/day after 2 days, then to 10 mg/day after another 2 days. Target dose, 10 mg/day; maximum dose, 30 mg/day.
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