Antiulcer Drugs
TERMS
□ aluminum hydroxide with magnesium hydroxide (Maalox)
□ cimetidine (Tagament)
□ omeprazole (Prilosec)
QUICK LOOK AT THE CHAPTER AHEAD
Peptic ulcer disease (PUD) involves the eating away of the stomach lining and other nearby areas of the GI tract and is most often caused by the bacteria, Helicobacter pylori (H. pylori).1 Approximately 10% of the US population experiences PUD at some time.1
There are several categories of drugs that are used to aid in the treatment of PUD. The combination of bismuth and antibiotics is used to remove the infection of H. pylori. There are currently three combination drugs that are used for this purpose: bismuth subsalicylate, metronidazole, and tetracycline (Helidac); amoxicillin, clarithromycin, and lansoprazole (Prevpac); and ranitidine and bismuth citrate (Tritec). Other groups of drugs used to control the acid produced in the stomach are Histamine-2 antagonists, proton pump inhibitors, antacids, and two miscellaneous drugs. These drug categories will be discussed in detail.
Table 62-1 Antiulcer Drugs | |||||||||||||||
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ANTIULCER DRUGS CLIENT TEACHINGHistamine-2 Antagonists
Do not breast-feed.
Report GI bleeding to physician.
Can take with or without food
No activities requiring concentration until drug effects are known.
No smoking, aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or alcohol
Do not abruptly stop drug.
Report GI bleeding to physician.Proton Pump Inhibitors
Do not breast-feed.
Report diarrhea and any urinary changes.
Report diarrhea and any urinary changes.Antacids
Take before and after meals and at hour of sleep.
Shake liquids.
Do not take other drugs with these drugs; separate by at least 1 hour.
If on low sodium diet, client must take antacid that is low sodium magaldrate (Riopan).
Chew tablets and take a full glass of milk or water afterwards.
Take before and after meals and at hour of sleep.
Do not take other drugs with these drugs; separate by at least 1 hour.
If on low sodium diet, client must take antacid that is low sodium magaldrate (Riopan).Miscellaneous Drugs
Misoprostol (Cytotec)
Do not breast-feed.
Do not get pregnant.
Report menstrual irregularities.
Don’t take magnesium antacids as this increases risk of diarrhea.
Don’t take magnesium antacids as this increases risk of diarrhea.Sucralfate (Carafate)
Do not breast-feed.
Prevent constipation via exercise, increased fluids, and fiber in diet.
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