Antilipemic Drugs



Antilipemic Drugs







TERMS



  • □ atorvastatin (Lipitor)


  • □ cholestyramine (Questran)


  • □ ezetimibe (Zetia)



QUICK LOOK AT THE CHAPTER AHEAD

The antilipemic drugs are indicated to lower cholesterol and triglycerides levels. The National Cholesterol Education Program recommends that nondrug therapy such as diet, exercise, and reduction of other risk factors should be tried first, for at least 6 months, and if not effective, then drug therapy may be indicated.1

The 4 major classifications of antilipemics include: bile acid sequestrants, fibric acid derivatives, HMG-CoA reduatase inhibitors, also known as “statins,” and cholesterol absorption inhibitors.









Table 44-1 Antilipemic Drugs

















































Prototype Drug

Related Drugs

Drug Classification


cholestyramine (Questran)

colestipol hydrochloride (Colestid)

Bile acid sequestrants


colesevelam (Welchol)


There is no prototype for this classification

fenofibrate (Tricor)

Fibric acid derivatives


gemfibrozil (Lopid)


atorvastatin (Lipitor)

fluvastatin (Lescol)

HMG-CoA reductase inhibitors (also called statins)


lovastatin (Mevacor)


pravastatin (Pravachol)


rosuvastatin (Crestor)


simvastatin (Zocor)


ezetimibe (Zetia)

There are no related drugs at this time

cholesterol absorption inhibitor


There is no prototype for this classification

niacin or nicotinic acid

Other/vitamin B3


There is no prototype for this classification

Caduet (amlodipine and atorvastatin)

Combination antilepemics


Niacin extended release/lovastatin (Advicor)


Pravigard (buffered aspirin and pravastatin)


Vytorin (ezetimibe and simvastatin)



ANTILIPEMIC DRUGS CLIENT TEACHING



  • Instruct client on proper nutrition and exercise.


  • Notify health care provider of continuous gastrointestinal (GI) upset or distress, bleeding, yellow skin discoloration, decreased libido, or dysuria.


  • Powder or granule preparations should be mixed with liquids or food.


  • Do not change or stop medication without consulting with health care provider.


  • Consult with health care provider before taking herbal remedies or OTC drugs.



  • Other drugs should be taken 1 hour before or 4 to 6 hours after bile acid sequestrants.


  • Periodic laboratory and clinical monitoring are indicated.


  • Notify health care provider immediately if experiencing muscle pain.



image Notify health care provider of continuous gastrointestinal (GI) upset or distress, bleeding, yellow skin discoloration, decreased libido, or dysuria.



image Notify health care provider immediately if experiencing muscle pain.


ACTION


Bile Acid Sequestrants



  • Combine with bile acids in the small intestine to form insoluble complexes excreted through stool, which reduces low-density lipoprotein (LDL) and serum cholesterol levels


Fibric Acid Derivatives

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Oct 21, 2016 | Posted by in NURSING | Comments Off on Antilipemic Drugs

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