Amiloride Hydrochloride(a mill’ oh ride)
Midamor
PREGNANCY CATEGORY B
Drug class
Potassium-sparing diuretic
Therapeutic Actions
Inhibits sodium reabsorption in the renal distal tubule, causing loss of sodium and water and retention of potassium.
Indications
Adjunctive therapy with thiazide or loop diuretics in heart failure and in hypertension to treat hypokalemia or to prevent hypokalemia in patients who would be at high risk if hypokalemia occurred (digitalized patients, patients with cardiac arrhythmias)
Unlabeled uses: Inhalation in the treatment of cystic fibrosis; reduction of lithium-induced polyuria without increasing lithium levels
Contraindications and Cautions
Contraindicated with allergy to amiloride, hyperkalemia, severe renal disease, diabetic nephropathy, potassium-rich diet.
Use cautiously with renal or hepatic disease, diabetes mellitus, metabolic or respiratory acidosis, lactation, pregnancy.
Available Forms
Tablets—5 mg
Dosages
Adults
Adjunctive therapy: Add 5 mg/day PO to usual antihypertensive or dosage of kaliuretic diuretic; if necessary, increase dose to 10 mg/day or to 15–20 mg/day with careful monitoring of electrolytes.
Single-drug therapy: Start with 5 mg/day PO; if necessary, increase to 10 mg/day or to 15–20 mg/day with careful monitoring of electrolytes.
Pediatric patients
Safety and efficacy not established.
Pharmacokinetics
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