Amantadine Hydrochloride(a man’ ta deen)
Endantadine (CAN), Gen-Amantadine (CAN), Symmetrel
PREGNANCY CATEGORY C
Drug Classes
Antiviral
Antiparkinsonian
Therapeutic Actions
May inhibit penetration of influenza A virus into the host cell; may increase dopamine release in the nigrostriatal pathway of patients with Parkinson’s disease, relieving their symptoms.
Indications
Prevention and treatment of influenza A virus respiratory infection, especially in high-risk patients
Adjunct to late vaccination against influenza A virus, to provide interim coverage; supplement to vaccination in immunodeficient patients; prophylaxis when vaccination is contraindicated
Treatment of Parkinson’s disease and drug-induced extrapyramidal reactions
Contraindications and Cautions
Contraindicated with allergy to drug product, psychoses, lactation.
Use cautiously with renal or hepatic disease, seizures, heart failure, pregnancy, eczematoid rash.
Available Forms
Tablets—100 mg; capsules—100 mg; syrup—50 mg/5 mL
Dosages
Adults
Influenza A virus prophylaxis: 200 mg/day PO or 100 mg bid PO for 10 days after exposure, for the duration of known influenza A in the community if vaccination is impossible and exposure is repeated. If used in conjunction with influenza vaccine, administer for 2–4 wk after vaccine has been given.
Uncomplicated influenza A virus treatment: Same dose as above; start treatment as soon after exposure as possible, continuing for 24–48 hr after symptoms are gone.
Parkinsonism treatment: 100 mg bid (up to 400 mg/day) PO when used alone; reduce in patients receiving other antiparkinsonian drugs. Use initial dose of 100 mg/day in patients with severe associated medical illnesses.
Drug-induced extrapyramidal reactions: 100 mg bid PO, up to 300 mg/day in divided doses has been used.
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