Adrenergic Blocking Agents
TERMS
□ prazosin (Minipress)
□ propranolol (Inderal)
QUICK LOOK AT THE CHAPTER AHEAD
The adrenergic blocking agents attach to the adrenergic receptor sites and prevent stimulation of the SNS. They are also called sympatholytics. Alpha receptors are located on nerves, organs, muscles, and cells throughout the body. When these receptors are blocked, the following occur: pupil constriction, lowered blood pressure, vasodilation, and suppressed ejaculation. The beta receptors are located on the smooth muscles of the blood vessels and bronchioles and on the heart.
Table 29-1 Adrenergic Blocking Agents | |||||||||
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ADRENERGIC BLOCKING AGENTS CLIENT TEACHINGAlpha Adrenergic Blocking Agents
Do not breast-feed.
Change position slowly.
No activities that require concentration until drug effects are known
Adverse effects tend to go away as dosing continues.
Drug should be taken at same time daily.
Learn how to take blood pressure and keep written record of what blood pressure was before each dose.
No OTC drugs unless you check with physician
Impotence needs to be reported-immediately.
Change position slowly.
Drug should be taken at same time daily.
Learn how to take blood pressure and keep written record of what blood pressure was before each dose.Beta Adrenergic Blocking Agents
Do not breast-feed.
No OTC drugs unless you check with physician
No activities that require concentration until drug effects are known
Do not stop drug abruptly.
Change position slowly.
Drug lowers intraocular pressure so all health care providers of the client need to be told.
Low blood pressure may occur.
Take drug exactly as prescribed.
May suppress signs of low blood glucose
Low blood pressure may occur.
May suppress signs of low blood glucose
ACTIONAlpha Adrenergic Blocking Agents
Prevent excitement of the SNS by competing with the neurotransmitter, norepinephrine at the adrenergic receptor site, or by occupation of the site without competition. Noncompetitive occupation is irreversible while the competitive occupation is reversible.
Beta Adrenergic Blocking Agents
Prevent stimulation of adrenergic receptor sites from epinephrine and norepinephrine, which in turn blocks the action of the SNS
USEAlpha Adrenergic Blocking Agents
Beta Adrenergic Blocking Agents
Myocardial infarction
Cardiac arrhythmias
Glaucoma
Hypertension
Angina
Prophylaxis for migraine headache
ADVERSE EFFECTS AND SIDE EFFECTSAlpha Adrenergic Blockng Agents
Pregnancy category C, except for doxazosin (Cardura) and tamsulosin (Flomax), which are category B
CNS: Drowsiness, sedation, headache, dizziness
CV: Tachycardia, hypotension, palpitations, edema
Derm: Rash, alopecia, itching
EENT: Tinnitus, blurred vision
F & E: Elevated BUN and serum uric acid
GI: Nausea, vomiting, constipation, diarrhea, abdominal pain
GU: Impotence, urinary incontinence and frequency
Other: Increased perspiration, nosebleed
Beta Adrenergic Blocking Agents
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